THERAPEUTIC TARGETING OF ALTERNATIVE SPLICING

Therapeutic targeting of alternative splicing

Gene transcription leads to the generation of pre-mRNA molecules the gel bottle audrey which contain both coding sequences (exons) and intervening non-coding sequences (introns).The primary transcript needs further processing which involves the excision of introns and ligation of exons.This process is called RNA splicing.Nearly all primary transcri

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Advanced Renal Pelvic Carcinoma Revealed after Treatment of a Staghorn Calculus by Endoscopic Combined Intrarenal Surgery

Renal pelvis carcinoma associated with staghorn calculus is a clinically rare 5326058hx condition.A 66-year-old man presented with flank pain due to an 8 cm complete staghorn calculus.We performed three lithotomies using endoscopic combined intrarenal surgery and carried out intraoperative biopsy.Histopathological examinations revealed a keratinize

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Effects of lift-assist device on trunk and shoulder kinematics

Background: Repetitive handling of heavy concrete blocks has been associated with the risk of low back and shoulder injuries among the masons.Several interventions have been proposed to reduce the risk of musculoskeletal disorders among the masons.A new intervention, a lift-assist handle, was tested in this study.Objective: The effectiveness of the

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Impact of Training with Additional Respiratory Dead Space on Spirometry and Exercise Respiratory Pattern in Cyclists

The aim of our 10-week-long experiment was to investigate the impact of training with additional dead space (DS) on spirometry and exercise respiration.Respiratory muscle training is applied to the development exercise capacity.Twenty cyclists were assigned to two groups: the experimental (E) and the control (C).All alarecre.com of them carried on

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